Hospital tests

10) Histamine/Methacholine/Mannitol Challenge Test – Why is this test done?

Female patient breathing into a spirometry tube, wearing nose clips

This test is done to show how your lungs respond to irritation and exercise at the same time. You are carefully monitored during the test by a physiologist. It will help your respiratory specialists to plan the most effective treatment for you.

The challenge test involves breathing in an irritant that may cause the airways to go into spasm and narrow in controlled conditions.

The three different methods use different types of ingredients that can cause irritation:

  • Histamine/ Methacholine cause inflammation of the airways causing symptoms.
  • Mannitol has a drying effect on the airways also causing usual symptoms.